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Diets effects on metabolic organs function

Sofia Nogueira

Histochemistry and Cell Biology


Diets effects can be really different, it always depends oh how mach you eat but also on how you eat.

Early-life consumption of unhealthy foods is recognized as a major contributor for the onset of metabolic dysfunction and its related disorders, including diabetes and nonalcoholic fatty liver disease.

The lifelong impact of early unhealthy eating habits that start at younger ages remains unclear.

To better understand the effects of diet, it is essential to evaluate the changes induced in metabolic organs and potential mechanisms underlying those changes.

To investigate the long-term effects of eating habits, young male rats were exposed to high-sugar and high-energy diets.

After 14 weeks, body composition was valutaded, and the changes were analyzed in the liver and adipose tissue.

The Serum biochemical parameters were also determined.

Expression of inflammatory markers in the liver was evaluated by immunohistochemistry.

The results revealed that serum levels of glucose, creatinine, aspartate transaminase, alanine transaminase, and lipid profile were increased in those rats.

Histopathological alterations were observed, including abnormal hepatocyte organization and lipid droplet accumulation in the liver, and abnormal structure of adipocytes.

It is confirmed that unhealthy diets bring functional and structural changes in the organs, suggesting that proinflammatory and oxidative stress mechanisms trigger the hepatic dysfunction.


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