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Age-dependent differences in breast tumor microenvironment: challenges and opportunities for efficac...
Immunity suffers a function deficit during aging, and the incidence of cancer is increased in the elderly. However, most cancer […]...
The Mechanistic Study of Mitochondrial Autophagy and Ferroptosis in the Progression of Decreased Ova...
Abstract Objective To investigate the mechanism in the progression of decreased ovarian reserve (DOR). Methods Three-month-old female SD rats were [&hellip...
Prediction of homologous recombination deficiency identifies colorectal tumors sensitive to PARP inh...
The synthetic lethal effect observed with the use of PARP inhibitors (PARPi) with tumors characterized by the loss of key […]...
Histology of pulmonary tuberculosis in a 19th-century mummy from Comiso (Sicily, Italy)...
Abstract Objective The aim of this study is to investigate potential evidence of tuberculosis in mummified remains. Materials The natural […]...
In vitro bioprinted 3D model enhancing osteoblast-to-osteocyte differentiation...
In vitro bone models are pivotal for understanding tissue behavior and cellular responses, particularly in unravelling certain pathologies’ mechanis...
Integrating bioinformatics and ferroptosis to reveal the protective mechanism of Astragaloside IV on...
Ferroptosis is an important pathological mechanism of chronic heart failure (CHF). This study aimed to investigate the protective mechanism of […]...
Targeting cancer-associated fibroblasts/tumor cells cross-talk inhibits intrahepaticcholangiocarcino...
Abstract Background Cancer-associated fibroblasts (CAFs), mainly responsible for the desmoplastic reaction hallmark of intrahepatic Cholangiocarcinoma (iCC...
Microscopic analysis of the digestive and reproductive tracts of male Silpha obscura (Coleoptera: ...
Silpha obscura Linnaeus, 1758 (Coleoptera: Silphidae) is an omnivorous beetle species known for damaging agricultural crops, making it an important target...
A respiratory mucosal vaccine based on chitosan/aluminum adjuvant induces both mucosal and systemic ...
The respiratory mucosa serves as a critical barrier against the invasion of pathogens. Effective mucosal vaccines are essential for enhancing […]...
Modelling human neuronal catecholaminergic pigmentation in rodents recapitulates age-related neurode...
One key limitation in developing effective treatments for neurodegenerative diseases is the lack of models accurately mimicking the complex physiopathology...
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