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Pharmacological inhibition of Lin28 promotes ketogenesis and restores lipid homeostasis in models of...
Abstract Lin28 RNA-binding proteins are stem-cell factors that play key roles in development. Lin28 suppresses the biogenesis of let-7 microRNAs […]...
Protein homeostasis regulation in breast tumor resilience...
Endoplasmic reticulum (ER) stress triggers an adaptive response in tumours which fosters cell survival and resilience to stress. Activation of […]...
Mcl-1 proteins and their relation with senolytic therapy...
Mcl-1 (Induced myeloid leukemia cell differentiation protein) is a protein that is encoded by the MCL1 gene in humans. Cells sub...
The Role of micro-RNA in pleural mesothelioma...
The Role of micro-RNA is a standard front-line treatment for pleural mesothelioma (PM) is pemetrexed-based chemotherapy, whose major target is […]...
Comparison of Different Tissue Clearing Methods for Three-Dimensional Reconstruction of Human Brain ...
The combination of tissue clearing techniques with advanced optical microscopy facilitates the achievement of three-dimensional (3D) reconstruction of macr...
Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidati...
Macrophages rely on tightly integrated metabolic rewiring to clear dying neighboring cells by efferocytosis during homeostasis and disease. Here we reveal ...
Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis...
Metastases account for most cancer-related deaths, yet the mechanisms underlying metastatic spread remain poorly understood....
Synthetic progestin negatively affects mating behavior...
High rates of progestins consumption in the form of active ingredients in women's oral contraceptives and other hormonal preparations may lead to their inc...
Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibitio...
Tumor-associated macrophages (TAMs) represent a major component of the tumor microenvironment supporting tumorigenesis. ...
Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T ...
The NUP214-ABL1 fusion is a constitutively activated tyrosine kinase that is significantly associated with overexpression of the TLX1 and TLX3 transcriptio...
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