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Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of...
Cellular senescence can exert dual effects in tumors, either suppressing or promoting tumor progression. The senescence-associated secretory phenotype (SAS...
Cyclodextrin microneedles for the delivery of a nanoparticle-based peptide antigen vaccin...
In recent years, microneedles (MNs) have gained considerable interest in drug formulation due to their non-invasive and patient-friendly nature. Dissolving...
Preclinical model of advanced prostate cancer...
Androgen deprivation therapy (ADT) is a standard therapy for prostate cancer (PCa). Though disseminated disease is initially sensitive to ADT, […]...
Control mechanism of DC cells in tumors...
Type 1 conventional dendritic cells (cDC1s) are critical for anti-cancer immunity. Protective anti-cancer immunity is thought to require cDC1s to […...
Pharmacological inhibition of Lin28 promotes ketogenesis and restores lipid homeostasis in models of...
Abstract Lin28 RNA-binding proteins are stem-cell factors that play key roles in development. Lin28 suppresses the biogenesis of let-7 microRNAs […]...
Protein homeostasis regulation in breast tumor resilience...
Endoplasmic reticulum (ER) stress triggers an adaptive response in tumours which fosters cell survival and resilience to stress. Activation of […]...
Mcl-1 proteins and their relation with senolytic therapy...
Mcl-1 (Induced myeloid leukemia cell differentiation protein) is a protein that is encoded by the MCL1 gene in humans. Cells sub...
The Role of micro-RNA in pleural mesothelioma...
The Role of micro-RNA is a standard front-line treatment for pleural mesothelioma (PM) is pemetrexed-based chemotherapy, whose major target is […]...
Comparison of Different Tissue Clearing Methods for Three-Dimensional Reconstruction of Human Brain ...
The combination of tissue clearing techniques with advanced optical microscopy facilitates the achievement of three-dimensional (3D) reconstruction of macr...
Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidati...
Macrophages rely on tightly integrated metabolic rewiring to clear dying neighboring cells by efferocytosis during homeostasis and disease. Here we reveal ...
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