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Epigenome-wide impact of MAT2A sustainsthe androgen-indifferent state and conferssynthetic vulnerabi...
Castration-resistant prostate cancer (CRPC) is a frequently occurring disease with adverse clinical outcomes and limited therapeutic options. Here, we iden...
Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves ...
Accumulating senescent cells within tissues contribute to the progression of aging and age-related diseases. Botanical extracts, rich in phytoconstituents,...
Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of...
Cellular senescence can exert dual effects in tumors, either suppressing or promoting tumor progression. The senescence-associated secretory phenotype (SAS...
Cyclodextrin microneedles for the delivery of a nanoparticle-based peptide antigen vaccin...
In recent years, microneedles (MNs) have gained considerable interest in drug formulation due to their non-invasive and patient-friendly nature. Dissolving...
Preclinical model of advanced prostate cancer...
Androgen deprivation therapy (ADT) is a standard therapy for prostate cancer (PCa). Though disseminated disease is initially sensitive to ADT, […]...
Control mechanism of DC cells in tumors...
Type 1 conventional dendritic cells (cDC1s) are critical for anti-cancer immunity. Protective anti-cancer immunity is thought to require cDC1s to […...
Pharmacological inhibition of Lin28 promotes ketogenesis and restores lipid homeostasis in models of...
Abstract Lin28 RNA-binding proteins are stem-cell factors that play key roles in development. Lin28 suppresses the biogenesis of let-7 microRNAs […]...
Protein homeostasis regulation in breast tumor resilience...
Endoplasmic reticulum (ER) stress triggers an adaptive response in tumours which fosters cell survival and resilience to stress. Activation of […]...
Mcl-1 proteins and their relation with senolytic therapy...
Mcl-1 (Induced myeloid leukemia cell differentiation protein) is a protein that is encoded by the MCL1 gene in humans. Cells sub...
The Role of micro-RNA in pleural mesothelioma...
The Role of micro-RNA is a standard front-line treatment for pleural mesothelioma (PM) is pemetrexed-based chemotherapy, whose major target is […]...
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