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Mechanism for protective anticancer immunity...
Type 1 conventional dendritic cells (cDC1) can support T cell responses within tumors but whether this determines protective versus ineffective anti-cance...
IFNγ signaling in cytotoxic T cells restricts anti-tumor responses by inhibiting the maintenance an...
Abstract IFNγ is an immune mediator with concomitant pro- and anti-tumor functions. Here, we provide evidence that IFNγ directly acts […]...
Soft gallstone-crushing robots...
Abstract The current treatment for symptomatic gallstones is primarily surgical, where one of the most general surgeries, laparoscopic cholecystectomy, is ...
Fibroblasts and lymph node homeostasis...
Abstract Emergent physical properties of tissues are not readily understood by reductionist studies of their constituent cells. Here, we show […]...
SIGIRR Negatively Regulates IL-36 Inflammation...
SIGIRR has been described as a negative regulator of several IL-1R/TLR family members and has been implicated in several inflammatory […]...
Oral treatment of 4-methylumbelliferone reduced perineuronal nets and improved recognition memory in...
Hyaluronan (HA) is a core constituent of perineuronal nets (PNNs) that surround subpopulations of neurones. The PNNs control synaptic stabilization [&helli...
COVID-eVax, an electroporated DNA vaccine...
The COVID-19 pandemic caused by SARS-CoV-2 has made the development of safe and effective vaccines a critical priority. To date, four vaccines have been ap...
Mineralocorticoid Receptor Antagonists Eplerenone and Spironolactone Modify Adrenal Cortex Morpholog...
Mineralocorticoid receptor antagonists (MRAs) are a class of anti-hypertensive drugs that act by blocking aldosterone action. The aim of this study was to ...
Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibitio...
Tumor-associated macrophages (TAMs) represent a major component of the tumor microenvironment supporting tumorigenesis. ...
Macrophage Liver Imprinted by Stellate Cells...
Macrophages are strongly adapted to their tissue of residence. Yet, little is known about the cell-cell interactions that imprint the tissue-specific ident...
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