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Pharmacological inhibition of Lin28 promotes ketogenesis and restores lipid homeostasis in models of...
Abstract Lin28 RNA-binding proteins are stem-cell factors that play key roles in development. Lin28 suppresses the biogenesis of let-7 microRNAs […]...
Heterogeneity in PHGDH protein expression potentiates cancer cell dissemination and metastasis...
Abstract Cancer metastasis requires the transient activation of cellular programs enabling dissemination and seeding in distant organs. Genetic, transcript...
A cellular hierarchy in melanoma uncouples growth and metastasis...
Abstract Although melanoma is notorious for its high degree of heterogeneity and plasticity1,2, the origin and magnitude of cell-state diversity remains [...
Effects of the synthetic progestin levonorgestrel on some aspects of thyroid physiology in common ca...
Abstract The objective of the present study was to assess the effects of levonorgestrel (LNG), a synthetic progestin, on early […]...
Decellularized Pancreatic Tailas Matrix for Pancreatic Islet Transplantation into the Greater Omentu...
Abstract Infusing pancreatic islets into the portal vein currently represents the preferred approach for islet transplantation, despite considerable loss o...
Protein homeostasis regulation in breast tumor resilience...
Endoplasmic reticulum (ER) stress triggers an adaptive response in tumours which fosters cell survival and resilience to stress. Activation of […]...
Fasting effect on tumor microenvironment and on immunotherapy efficacy...
Immunotherapy is improving the prognosis and survival of cancer patients, but despite encouraging outcomes in different cancers, the majority of […]...
Protective function of natural autoantibodies in rhabdomyosarcoma...
Immunoreactivity against fibroblast growth factor 8 in alveolar rhabdomyosarcoma patients and its involvement in tumor aggressiveness...
Ubiquitin role in glioblastoma growth...
Abstract Glioblastoma multiforme (GBM) is the most frequent and aggressive form of primary brain tumor in the adult population; its […]...
Diets effects on metabolic organs function...
Diets effects can be really different, it always depends oh how mach you eat but also on how you eat. […]...
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