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Age-dependent differences in breast tumor microenvironment: challenges and opportunities for efficac...
Immunity suffers a function deficit during aging, and the incidence of cancer is increased in the elderly. However, most cancer […]...
A Highly Standardized Pre-Clinical Porcine Wound Healing Model Powered by Semi-Automated Histologica...
The wound-healing process is a physiological response that begins after a disruption to the integrity of tissues present in the […]...
Salicylic acid and RNA interference mediate antiviral immunity of plant stem cells...
Stem cells are essential for the development and organ regeneration of multicellular organisms, so their infection by pathogenic viruses must […]...
Fluid shear stress induces a shift from glycolytic to amino acid pathway in human trophoblasts...
Abstract Background The human placenta, a tissue with a lifespan limited to the period of pregnancy, is exposed to varying […]...
Response of Primary Glioblastoma Patients Treated with Temozolomide...
Glioblastoma is the most common malignant brain tumor in adults. Standard treatment includes tumor resection, radio-chemotherapy and adjuvant chemotherapy ...
Platelet-derived factors dysregulate placental sphingosine-1-phosphate receptor 2 in human trophobla...
Abstract Research question Sphingosine-1-phosphate (S1P) is an essential and bioactive sphingolipid with various functions, which acts through five differe...
Control mechanism of DC cells in tumors...
Type 1 conventional dendritic cells (cDC1s) are critical for anti-cancer immunity. Protective anti-cancer immunity is thought to require cDC1s to […...
Anatomical basis of retrograde thoracic veins flow and its implications in complex thoracic wall rec...
Abstract Purpose: Internal thoracic veins are increasingly used as recipient’s vessels in chest wall reconstructive surgery due to their predictable [&he...
SCON—a Short Conditional intrON for conditional knockout with one-step zygote injection...
Abstract The generation of conditional alleles using CRISPR technology is still challenging. Here, we introduce a Short Conditional intrON (SCON, […...
Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis...
Abstract The generation of high-affinity antibodies against pathogens and vaccines requires the germinal center (GC) reaction, which relies on a […]...
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